Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieCell Survival
CeRNA1eGFP-miR-155 sponge[Artifically engineered RNA]
miRNAmiR-155[miRNA]
CeRNA2JARID2[mRNA]
Tissue/Cell lineB-Cell Lymphomas
SpecieHomo sapiens (human)
CitationJ Virol 2009 Dec 83, 12009-17 doi:10.1128/jvi.01182-09 PMID:19759154
Reference title
Reticuloendotheliosis virus strain T induces miR-155, which targets JARID2 and promotes cell survival
Experimental verification
Reporter assay;Other
Functional description
Eight miR-155 target sites with a bulge from nt 9 to 12 were cloned into the 3'UTR of the MS2 viral coat protein. We first investigated the functionality of the miR-155 sponge by the luciferase assay. In the presence of miR-155, luciferase levels of JARID2 3'UTR were reduced. With increasing amounts of miR-155 sponge, miR-155 function was inhibited and the repression of luciferase JARID2 3'UTR was abrogated
Annotations
External Annotation for eGFP-miR-155 sponge |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
