Data type	Species	Disease	Gene	Title	Result	PMID	Details
High throughput	Homo sapiens	MS	NPY, KANK4, NCAN, TKTL1, and ANO4	Gene Expression Profiling of Multiple Sclerosis Pathology Identifies Early Patterns of Demyelination Surrounding Chronic Active Lesions	we found regulation of novel genes in and around the rim of chronic active lesions, such as NPY, KANK4, NCAN, TKTL1, and ANO4.	29312322	Details
High throughput	Homo sapiens	MS	Significant differences in gene expression were confirmed for CHIT1, GPNMB, CCL18, KANK4, OLR1, CD68, MSR1, and CXCL16 in comparison I; for NPY, OLR1, CD68, and MSR1 in comparison II; and for GPNMB, OLR1, CD68, and MSR1 in comparison III.	Gene Expression Profiling of Multiple Sclerosis Pathology Identifies Early Patterns of Demyelination Surrounding Chronic Active Lesions	This resulted in a total of 1,251 significantly regulated genes in comparison I, 587 genes in comparison II, and 3,434 genes in comparison III.Some genes were generally expressed lower (cluster 1) or higher (cluster 2) in all lesion subregions, compared to control tissue.The other four patterns followed the presumed sequence of MS lesion development with a peak of gene expression around chronic active lesions (cluster 3), a peak of gene expression in the rim of chronic active lesions (cluster 4), low gene activity around active rims, but high expression in active rims and (peri)-rims of inactive lesions (cluster 5), and high gene expression in and around inactive lesions, but low activity in active rims (cluster 6).	29312322	Details