LncRNA NameHOTAIR
Variant TypeSNP
Variant IDrs920778
Specieshuman
Circulating
Survival
CeRNA
Methylation
Enhancer
Drug
Disease/Traitgastric cancer
LncRNA Target GeneHER2
Tissuegastric cancer tissue, (AGS, MGC803) cell lines
Experimentgenotyping, luciferse reporter assay, real-time PCR
Function DescriptionThe rs920778 C>T SNP located in the intronic enhancer region alters the activity of this regulatory element. This may lead to increased HOTAIR expression, which conferring the underlying mechanism of gastric cancer susceptibility.
Pubmed ID25640751
Year2016
TitleA Functional lncRNA HOTAIR Genetic Variant Contributes to Gastric Cancer Susceptibility
External Links
Links For HOTAIRGeneCards HGNC NONCODE LncRNAWiki lncrnadb
Links For gastric cancerOMIM Cosmic
Links For rs920778 dbSNP ClinVar OMIM