LncRNA NameMIR2052HG
Variant TypeSNP
Variant IDMA.27
Specieshuman
Circulating
Survival
CeRNA
Methylation
Enhancer
Drug
Disease/Traithepatocellular carcinoma
LncRNA Target GeneLMTK3
Tissuetissue
Experimentluciferase activity assay,RNA-binding protein immunoprecipitation,Chromatin immunoprecipitation (ChIP),western blotting,qRT-PCR
Function DescriptionThe variant SNP increased EGR1 binding to LMTK3 promoter in response to androstenedione, relative to wild-type genotype, a pattern that can be reversed by aromatase inhibitor treatment. LMTK3
Pubmed ID30944027
Year2019
TitleThe lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1
External Links
Links For MIR2052HGGeneCards HGNC NONCODE LncRNAWiki lncrnadb
Links For hepatocellular carcinomaOMIM Cosmic
Links For MA.27 dbSNP ClinVar OMIM