Detailed information
| LncRNA Name | ANRIL |
| Variant Type | SNP |
| Variant ID | rs564398 |
| Species | human |
| Circulating | ✓ |
| Survival | ✕ |
| CeRNA | ✕ |
| Methylation | ✕ |
| Enhancer | ✕ |
| Drug | ✕ |
| Disease/Trait | acute lymphoblastic leukemia |
| LncRNA Target Gene | CDKN2BAS |
| Tissue | acute lymphoblastic leukemia tissues |
| Experiment | MassARRAY assay etc. |
| Function Description | Rs564398 (A>G), mapping to the CDKN2BAS locus that encodes for ANRIL antisense non-coding RNA, showed a statistically significant correlation with the ALL phenotype, with a risk pattern that was compatible with an overdominant model of disease susceptibility. We hypothesized that this association reflects the capability of some ANRIL polymorphisms to contribute to its transcription changes responsible for alterations of CDKN2A/B expression profiles, thus leading to abnormal proliferative boosts and consequent increased ALL susceptibility. |
| Pubmed ID | 21414664 |
| Year | 2011 |
| Title | A polymorphism in the chromosome 9p21 ANRIL locus is associated to Philadelphia positive acute lymphoblastic leukemia. |
| External Links | |
|---|---|
| Links For ANRIL | GeneCards HGNC NONCODE LncRNAWiki lncrnadb |
| Links For acute lymphoblastic leukemia | OMIM Cosmic |
| Links For rs564398 | dbSNP ClinVar OMIM |