| Function Description | Here, we show that the long ncRNA CCAT2, located at the 8q24 amplicon on cancer risk-associated rs6983267 SNP, regulates cancer metabolism in vitro and in vivo in an allele-specific manner by binding the Cleavage Factor I (CFIm) complex with distinct affinities for the two subunits (CFIm25 and CFIm68).Moreover, when we assessed the proliferation of HCT116 control and CCAT2-overexpressing cells treated with the GLS inhibitor 968, we found that cells overexpressing CCAT2 were more sensitive to GLS (GAC in this case) inhibition, implying that cells with high CCAT2 expression are dependent on GAC for survival. |