| Disease/Trait | papillary thyroid cancer |
| LncRNA Target Gene | NA |
| Tissue | PTC tissues, PTC cell lines (TPC-1 and IHH-4) |
| Experiment | Microarray, qRT-PCR, Western blot, Luciferase reporter assay, RIP |
| Function Description | The genomic copy number of CNALPTC1 is amplified and CNALPTC1 expression level is up-regulated in PTC.CNALPTC1 physically associates to miR-30 family and down-regulates miR-30 expression. Furthermore, CNALPTC1 up-regulates the expression of miR-30 targets, such as BCL9, SNAI1, and VIM. The mutation of miR-30 binding site on CNALPTC1 or overexpression of miR-30 abrogates the oncogenic roles of CNALPTC1 in PTC. |
| Pubmed ID | 29416932 |
| Year | 2018 |
| Title | Long noncoding RNA CNALPTC1 promotes cell proliferation and migration of papillary thyroid cancer via sponging miR-30 family. |