| Disease/Trait | pancreatic ductal adenocarcinoma |
| LncRNA Target Gene | NA |
| Tissue | cell lines (PANC-1 PANC1, BxPC3, MiaPaCa2 and Aspc1) |
| Experiment | RNA-seq, qrT-PCR, Western blot |
| Function Description | We identified lncRNAs in genomic regions with SCNA and single nucleotide polymorphisms associated with lifetime risk of PDA and associated with clinical outcome using genomic and clinical data in PDA. Systems biology and experimental functional analysis of two epithelial lncRNAs (LINC00673 and FAM83H-AS1) suggest they regulate the transcriptional profile of pancreatic tumour samples and PDA cell lines.We also detected lncRNAs located in proximity to GATA6 and FOXA2, both important transcription factors involved in pancreas development. PDA is characterised by high penetrance mutations in four genes (KRAS, TP53, CDKN2A and SMAD4). We performed a similar analysis and identified five candidate lncRNAs within loci that harboured somatic SNP variants associated with increased risk of PDA |
| Pubmed ID | 29440233 |
| Year | 2018 |
| Title | Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma. |