| Disease/Trait | oral squamous cell carcinoma |
| LncRNA Target Gene | MRPL23-AS1 |
| Tissue | oral squamous cell carcinoma tissues, cell lines (Cal-27 and HN-4) |
| Experiment | qPCR, Luciferase reporter assay |
| Function Description | Two SNPs, rs217727 and rs2839701, were found to be associated with the risk of OSCC [rs217727: odds ratio (OR) = 1.32, 95% confidence interval (CI) = 1.11-1.58, P = 0.002; rs2839701: OR = 1.23, 95% CI = 1.04-1.46, P = 0.019].Bioinformatics predicted that rs2839701 C>G might alter the secondary structure of H19. In addition, rs2839701 C>G inhibited the transcription activity and was correlated with the decreased expression of downstream gene MRPL23-AS1 that was downregulated in OSCC. |
| Pubmed ID | 29844862 |
| Year | 2018 |
| Title | Genetic Variants in lncRNA H19 Are Associated With the Risk of Oral Squamous Cell Carcinoma in a Chinese Population |