Detailed information
| LncRNA Name | H19 |
| Variant Type | SNP |
| Variant ID | rs27359703 |
| Species | human |
| Circulating | ✓ |
| Survival | ✓ |
| CeRNA | ✕ |
| Methylation | ✕ |
| Enhancer | ✕ |
| Drug | ✕ |
| Disease/Trait | colorectal cancer |
| LncRNA Target Gene | NA |
| Tissue | blood |
| Experiment | qPCR;Other |
| Function Description | 3 SNPs of rs4930101, rs11042170, and rs27359703 among 16 identified SNPs of H19 gene remarkably increased CRC risk. Furthermore, the combined risk genotypes had a significant impact on environmental factors and clinical outcomes in the advanced CRC patients with body weight ≥ 61 kg, ever-smoking, and first-degree family history of cancer. These data suggest that H19 promoter SNPs, especially these combined SNPs might be more potentially functional biomarkers in the prediction of advanced CRC risk and prognosis. |
| Pubmed ID | 31452627 |
| Year | 2019 |
| Title | Functional Polymorphisms of the lncRNA H19 Promoter Region Contribute to the Cancer Risk and Clinical Outcomes in Advanced Colorectal Cancer |
| External Links | |
|---|---|
| Links For H19 | GeneCards HGNC NONCODE LncRNAWiki lncrnadb |
| Links For colorectal cancer | OMIM Cosmic |
| Links For rs27359703 | dbSNP ClinVar OMIM |