LncRNA NameHOTAIR
Variant TypeSNP
Variant IDrs4759314
Specieshuman
Circulating
Survival
CeRNA
Methylation
Enhancer
Drug
Disease/Traitcervical cancer
LncRNA Target GeneNA
Tissueblood
ExperimentqPCR;Other
Function DescriptionHowever, genotype GG in lncRNAs HOTAIR SNP rs920778 was demonstrated to be a predictor for poorer cancer recurrence probability [p=0.001, hazard ratio (HR): 7.25, 95% CI: 2.19-23.96]. Furthermore, cervical cancer patients with genotype GG in lncRNAs HOTAIR rs920778 had worse overall survival (p =0.002, HR: 7.22, 95% CI: 2.09-24.92). No significant associations exhibited between lncRNAs HOTAIR SNP rs920778 and clinicopathological parameters. In conclusion, this studied lncRNAs HOTAIR SNPs are not associated with cervical carcinongensis. However, lncRNAs HOTAIR SNP rs920778 may be regarded as an independent predictor of cancer recurrence probability and overall survival in cervical cancer patients.
Pubmed ID30275757
Year2018
TitleSignificant Association of Long Non-Coding RNAs HOTAIR Genetic Polymorphisms With Cancer Recurrence and Patient Survival in Patients With Uterine Cervical Cancer
External Links
Links For HOTAIRGeneCards HGNC NONCODE LncRNAWiki lncrnadb
Links For cervical cancerOMIM Cosmic
Links For rs4759314 dbSNP ClinVar OMIM