Detailed information
| LncRNA Name | HOTAIR |
| Variant Type | SNP |
| Variant ID | rs4759314 A>G |
| Species | human |
| Circulating | ✓ |
| Survival | ✓ |
| CeRNA | ✕ |
| Methylation | ✕ |
| Enhancer | ✕ |
| Drug | ✕ |
| Disease/Trait | gastric cardia adenocarcinoma |
| LncRNA Target Gene | NA |
| Tissue | blood |
| Experiment | qPCR, RFLP-PCR etc. |
| Function Description | Among three htSNPs of the HOTAIR gene (rs12826786 C>T, rs4759314 A>G, and rs10783618 C>T), only the T allele of rs12826786 was found to increase the risk of developing GCA and was associated with smoking habit and tumor-node-metastasis (TNM) stage. In addition, higher expression levels of HOTAIR were found in tumor tissues and rs12826786 SNP has a genotype-specific effetc on HOTAIR expression. A high HOTAIR expression level was associated with poor GCA patients' survival. |
| Pubmed ID | 25476857 |
| Year | 2014 |
| Title | Associations between polymorphisms of HOTAIR and risk of gastric cardia adenocarcinoma in a population of north China. |
| External Links | |
|---|---|
| Links For HOTAIR | GeneCards HGNC NONCODE LncRNAWiki lncrnadb |
| Links For gastric cardia adenocarcinoma | OMIM Cosmic |
| Links For rs4759314 A>G | dbSNP ClinVar OMIM |