LncRNA Name	HOXA11-AS
Variant Type	SNP
Variant ID	rs17427875
Species	human

Circulating	✕
Survival	✓
CeRNA	✕
Methylation	✕
Enhancer	✕
Drug	✕

Disease/Trait	ovarian cancer
LncRNA Target Gene	NA
Tissue	ovarian cancer tissues
Experiment	qPCR, Western blot etc.
Function Description	Functional studies of ectopic expression of HOXA11-AS minor allele T in EOC cells showed decreased survival, proliferation, migration, and invasion compared to common allele A expression. Additionally, stable expression of HOXA11-AS minor allele T reduced primary tumor growth in mouse xenograft models to a greater extent than common allele A. Furthermore, HOXA11-AS expression levels were significantly lower in human EOC tumors than normal ovarian tissues, suggesting that HOXA11-AS has a tumor suppressor function in EOC which may be enhanced by the T allele
Pubmed ID	26430965
Year	2015
Title	A functional variant in HOXA11-AS, a novel long non-coding RNA, inhibits the oncogenic phenotype of epithelial ovarian cancer

External Links
Links For HOXA11-AS	GeneCards HGNC NONCODE LncRNAWiki lncrnadb
Links For ovarian cancer	OMIM Cosmic
Links For rs17427875	dbSNP ClinVar OMIM