Detailed information

LncRNA NameLINC00673
Variant TypeSNP
Variant IDrs11655237
Specieshuman
Circulating✕
Survival✕
CeRNA✓
Methylation✕
Enhancer✕
Drug✕
Disease/Traitgastric cancer
LncRNA Target GenemiR-1231
Tissuegastric cancer and paired adjacent normal tissues ,BGC-803 cell line
ExperimentqRT-PCR ,Luciferase reporter assay etc.
Function DescriptionWe found rs11655237 significantly increased susceptibility of GC in the Chinese population , and a significant interaction was found between rs11655237 and Helicobacter pylori infection.Expression of LINC00673 was significantly higher in adjacent normal tissues than in paired cancer tissues and significantly lower in the cancer or paired adjacent normal tissues of GC patients with rs11655237 allele A than in those with rs11655237 allele G.Mechanism exploration found that, the construct with the rs11655237[A] allele had significantly reduced luciferase activity in the presence of miR-1231, and this effect could be completely rescued when miR-1231 inhibitor was present.
Pubmed ID31118802
Year2019
TitleFunctional variants of lncRNA LINC00673 and gastric cancer susceptibility: a case-control study in a Chinese population
External Links
Links For LINC00673GeneCards HGNC NONCODE LncRNAWiki lncrnadb
Links For gastric cancerOMIM Cosmic
Links For rs11655237 dbSNP ClinVar OMIM