| Disease/Trait | renal cell carcinoma |
| LncRNA Target Gene | EZH2 |
| Tissue | ccRCC tissues and cell lines (786-O, A498, 769P,Caki-2, Caki-1, ACHN, OS-RC-2, and SN12-PM6) |
| Experiment | qPCR;Western blot;RIP;RNAi;Other |
| Function Description | Furthermore, we observed that the level of LINC-PINT depended on gender as well as on pT and TNM stage of patients with ccRCC. Moreover, patients with high LINC-PINT expression had poor disease-free survival and overall survival. Functionally, overexpression of LINC-PINT promoted ccRCC cell proliferation, induced cell cycle progression, and inhibited apoptosis. LINC-PINT was primarily located in cell nuclei and interacted with EZH2. When EZH2 was knocked down in 769P and OS-RC-2 cells overexpressing LINC-PINT, the effect of LINC-PINT on cell proliferation, cell cycle, and apoptosis was partially reversed. Additionally, inducing p53 by doxorubicin (Dox) promoted LINC-PINT expression. |
| Pubmed ID | 31417274 |
| Year | 2019 |
| Title | Long Noncoding RNA LINC-PINT Promotes Proliferation Through EZH2 and Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma |