| Disease/Trait | colorectal cancer |
| LncRNA Target Gene | NA |
| Tissue | colorectal cancer tissues , cell line( HT-29) |
| Experiment | qPCR,Luciferase reporter assay etc |
| Function Description | lncRNA MALAT1 was upregulated, while hsa-miR-194-5p was downregulated, in cancer tissues of CRC patients.The risk of CRC was relatively higher among MALAT1 rs664589 G allele carriers, and the CRC patients with a G allele had a lower PFS. The likely mechanism underlying these observations is that the rs664589 SNP affects the binding efficiency between the lncRNA MALAT1 and the miRNA has-miR-194-5p, although this awaits laboratory confirmation |
| Pubmed ID | 32349546 |
| Year | 2020 |
| Title | MicroRNA Binding Site Polymorphisms of the Long-Chain Noncoding RNA MALAT1 are Associated with Risk and Prognosis of Colorectal Cancer in Chinese Han Population. |