| Disease/Trait | colorectal cancer |
| LncRNA Target Gene | NA |
| Tissue | Human CRC cells (SW480 and SW620), CRC tissues and the corresponding adjacent 17 noncancerous tissues, |
| Experiment | qPCR, Western blot, Luciferase reporter assay, RIP |
| Function Description | MALAT1 rs664589 CG/GG genotypes significantly increased the associated risk and decreased overall survival of patients with colorectal cancer compared with the CC genotype. In vitro and in vivo experiments showed that the rs664589 C to G mutation facilitated carcinogenesis and metastasis of colorectal cancer. Mechanistically, the miRNA miR-194-5p targeted MALAT1 for degradation in the nucleus in an Ago2-dependent manner; the rs664589 G allele altered the binding of MALAT1 to miR-194-5p, resulting in increased expression of MALAT1. Colorectal cancer cells and human tissues with the rs664589 CG/GG genotype expressed significantly higher MALAT1 than those with the rs664589 CC genotype. Multivariate Cox regression analysis showed that MALAT1 was a poor prognostic factor of colorectal cancer. |
| Pubmed ID | 31311811 |
| Year | 2019 |
| Title | MALAT1 rs664589 polymorphism inhibits binding to miR-194-5p 2 contributing to colorectal cancer risk, growth and metastasis |