| Disease/Trait | nasopharyngeal cancer |
| LncRNA Target Gene | NA |
| Tissue | cell lines (C666-1, HK-1, NP69, NP361 and NP460) |
| Experiment | qPCR, MSP-PCR, Western blot, FISH etc. |
| Function Description | In the present study, two MEG3 variants, AF119863 (MEG3-AF) and BX247998 (MEG3-BX), were found abundantly expressed in a normal nasopharyngeal epithelial cell line, NP69. Significant downregulation of MEG3-AF was further verified in a panel of NPC samples including xenografts and primary biopsies. Besides, ectopic expression of MEG3 in NPC cell lines resulted in considerable repression of in vitro anchorage-independent growth and in vivo tumorigenicity, in addition to significant inhibition in cell proliferation, colony formation, and induction of cell cycle arrest. |
| Pubmed ID | 27597634 |
| Year | 2017 |
| Title | Downregulation of long non-coding RNA MEG3 in nasopharyngeal carcinoma. |