| Disease/Trait | esophageal squamous cell carcinoma |
| LncRNA Target Gene | NA |
| Tissue | ESCC tissues, cell lines (TE1, TE13, T.Tn, Yes-2, and Eca109) |
| Experiment | qPCR, Cell proliferation assay etc. |
| Function Description | The expression level of lincRNA-NR_024015 in ESCC tumor tissues was significantly higher than that in corresponding normal tissues and rs8506 genotype has a genotype-specific effect on lincRNA-NR_024015 expression. Furthermore, rs8506 G to A variant might influence lincRNA-NR_024015 expression and function by disrupting the binding of hsa-miR-526b to the site. High expression level of lincRNA-NR_024015 and rs8506 A allele were associated with poor ESCC patients' survival. |
| Pubmed ID | 27583835 |
| Year | 2016 |
| Title | A genetic polymorphism at miR-526b binding-site in the lincRNA-NR_024015 exon confers risk of esophageal squamous cell carcinoma in a population of North China. |