Detailed information
| LncRNA Name | PVT1 |
| Variant Type | copy number variation |
| Variant ID | MYC locus |
| Species | human |
| Circulating | ✕ |
| Survival | ✓ |
| CeRNA | ✕ |
| Methylation | ✕ |
| Enhancer | ✕ |
| Drug | ✕ |
| Disease/Trait | ovarian cancer |
| LncRNA Target Gene | NA |
| Tissue | cell lines (A2780, DOV13, PA-1 etc.) |
| Experiment | qPCR etc. |
| Function Description | These results suggest that MYC and PVT1 contribute independently to ovarian and breast pathogenesis when overexpressed because of genomic abnormalities. They also suggest that PVT1-mediated inhibition of apoptosis may explain why amplification of 8q24 is associated with reduced survival duration in patients treated with agents that act through apoptotic mechanisms. |
| Pubmed ID | 17908964 |
| Year | 2007 |
| Title | Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer. |
| External Links | |
|---|---|
| Links For PVT1 | GeneCards HGNC NONCODE LncRNAWiki lncrnadb |
| Links For ovarian cancer | OMIM Cosmic |
| Links For MYC locus | dbSNP ClinVar OMIM |