Detailed information
| LncRNA Name | PVT1 |
| Variant Type | SNP |
| Variant ID | rs378854 |
| Species | human |
| Circulating | ✕ |
| Survival | ✕ |
| CeRNA | ✕ |
| Methylation | ✕ |
| Enhancer | ✕ |
| Drug | ✕ |
| Disease/Trait | prostate cancer |
| LncRNA Target Gene | PVT1 |
| Tissue | cell lines (PC3, 1542-CP) |
| Experiment | qPCR, ChIP etc. |
| Function Description | The risk allele (G) of rs378854 (A>G) reduces binding of the transcription factor YY1 in vitro. The region surrounding rs378854 interacts with the MYC and PVT1 promoters.Expression of the PVT1 oncogene in normal prostate tissue increased with the presence of the risk allele of rs378854, while expression of MYC was not affetced. |
| Pubmed ID | 21814516 |
| Year | 2011 |
| Title | A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression. |
| External Links | |
|---|---|
| Links For PVT1 | GeneCards HGNC NONCODE LncRNAWiki lncrnadb |
| Links For prostate cancer | OMIM Cosmic |
| Links For rs378854 | dbSNP ClinVar OMIM |