| Disease/Trait | clear cell renal cell carcinoma |
| LncRNA Target Gene | miR-200s |
| Tissue | clear cell renal cell carcinoma tissues, cell lines (293T, ACHN and HK-2) |
| Experiment | qPCR, Luciferase assays etc. |
| Function Description | Plasmacytoma variant translocation 1 (PVT1),was shown to be upregulated in clear cell renal cell carcinoma (ccRCC) in our study, while Kaplan-Meier curve and Cox regression analysis showed that high expression of PVT1 was associated with poor overall survival (OS) and disease free survival (DFS) in ccRCC patients.PVT1 could function as an oncogenic transcript partly through sponging miR-200s to regulate BMI1, ZEB1 and ZEB2 expression. |
| Pubmed ID | 29156724 |
| Year | 2017 |
| Title | lncRNA PVT1 and its splicing variant function as competing endogenous RNA to regulate clear cell renal cell carcinoma progression. |