Detailed information
| LncRNA Name | SIRT1-AS |
| Variant Type | SNP |
| Variant ID | A 763-nucleotide (nt), single-exon NAT transcribed from the antisense strand of SIRT1 gene（622U>C） |
| Species | human |
| Circulating | ✕ |
| Survival | ✕ |
| CeRNA | ✓ |
| Methylation | ✕ |
| Enhancer | ✕ |
| Drug | ✕ |
| Disease/Trait | hepatocellular carcinoma |
| LncRNA Target Gene | miR-29c |
| Tissue | cell line (HCC-9903) |
| Experiment | qPCR, RNAi, Western blot, Northern blot etc. |
| Function Description | SIRT1-AS overexpression promoted the proliferation of the human HCC cell lines by upregulating the SIRT1 protein level. The mechanism was that SIRT1-AS bound to SIRT1 mRNA at 3'UTR, masked the miR-29c binding site and stabilized SIRT1 mRNA. |
| Pubmed ID | 26324025 |
| Year | 2015 |
| Title | A novel mutation in SIRT1-AS leading to a decreased risk of HCC |
| External Links | |
|---|---|
| Links For SIRT1-AS | GeneCards HGNC NONCODE LncRNAWiki lncrnadb |
| Links For hepatocellular carcinoma | OMIM Cosmic |
| Links For A 763-nucleotide (nt), single-exon NAT transcribed from the antisense strand of SIRT1 gene（622U>C） | dbSNP ClinVar OMIM |