| Disease/Trait | non small cell lung cancer |
| LncRNA Target Gene | NA |
| Tissue | NSCLC tissues, cell lines (A549, U-87 MG) |
| Experiment | qPCR, RNAi, Flow cytometry assay etc. |
| Function Description | Our data revealed that SOX2OT variants 4 and 7 were upregulated around six times in lung tumor tissues, compared to their non-tumor counterparts. The SOX2OT knockdown significantly reduced the colony formation ability of cancer cells; however, no alterations in the rate of apoptosis were detected. On the other hand, SOX2OT-suppressed cells had elevated accumulation in G2/M phase of cell cycle and exhibited limited mobility. |
| Pubmed ID | 26846097 |
| Year | 2016 |
| Title | Overexpression of the non-coding SOX2OT variants 4 and 7 in lung tumors suggests an oncogenic role in lung cancer. |