LncRNA NameZNRD1-AS1
Variant TypeSNP
Variant IDrs9261204
Specieshuman
Circulating
Survival
CeRNA
Methylation
Enhancer
Drug
Disease/Traitlung cancer
LncRNA Target GeneNA
Tissueblood
ExperimentqPCR, Genotyping etc.
Function Descriptionwe first evaluated the expression ZNRD1-AS1 and ZNRD1 among lung cancer tissues and corresponding normal tissues, which showed higher expression of ZNRD1-AS1 and lower expression of ZNRD1. To reveal the underlying mechanisms, we then investigated the associations between ZNRD1 eQTLs SNPs in ZNRD1-AS1 and risk of lung cancer in Han Chinese populations. G allele of SNP rs9261204 was significantly associated with an increased risk of lung cancer when compared with A allele. A weaker, but similar effect was also observed in bladder cancer. SNP rs3757328 was also associated with increased risk of lung cancer.
Pubmed ID27166266
Year2016
TitleStrong evidence for LncRNA ZNRD1-AS1, and its functional Cis-eQTL locus contributing more to the susceptibility of lung cancer
External Links
Links For ZNRD1-AS1GeneCards HGNC NONCODE LncRNAWiki lncrnadb
Links For lung cancerOMIM Cosmic
Links For rs9261204 dbSNP ClinVar OMIM