| Disease/Trait | breast cancer |
| LncRNA Target Gene | miRNA-370 |
| Tissue | breast cancer tissue, (MCF-7, Bcap-37) cell lines |
| Experiment | genotyping, luciferase reporter assay, real-time PCR |
| Function Description | The C allele of the rs12325489C>T polymorphism in the exonic regions of lincRNA-ENST00000515084 was associated with a significantly increased risk of breast cancer, compared with the rs12325489TT genotype.The C to T base change at rs12325489 C>T disrUp regulationts the binding site for miRNA-370, thereby influencing the transcriptional activity of lincRNA-ENST00000515084, and affecting cell proliferation and tumor growth. |
| Pubmed ID | 24879036 |
| Year | 2014 |
| Title | A Polymorphism rs12325489C.T in the LincRNAENST00000515084 Exon Was Found to Modulate Breast Cancer Risk via GWAS-Based Association Analyses |