| Disease/Trait | prostate cancer |
| LncRNA Target Gene | ONECUT2 |
| Tissue | cell lines(LNCaP, 22RV1, VCaP) |
| Experiment | siRNA transfection; enhancer reporter assays; ChIP–qPCR; ChIRP assays; immunoprecipitation and immunoblotting |
| Function Description | We further evaluated the mechanism underlying the top hit, PCAT1, and found that a risk-associated variant at rs7463708 increases binding of ONECUT2, a novel androgen receptor (AR)-interacting transcription factor, at a distal enhancer that loops to the PCAT1 promoter, resulting in upregulation of PCAT1 upon prolonged androgen treatment. |
| Pubmed ID | 27526323 |
| Year | 2016 |
| Title | Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer |