| Disease/Trait | esophageal squamous cell carcinoma |
| LncRNA Target Gene | micro-RNA-149 |
| Tissue | esophageal squamous cell carcinoma tissue |
| Experiment | genotyping, real-time PCR, luciferase reporter assay |
| Function Description | Compared with the A allele, the rs11752942G allele could markedly attenuate the level of lincRNA-uc003opf.1 both in vivo and in vitro by binding micro-RNA-149*, thereby affecting cell proliferation and tumor growth. Compared with the rs11752942AA genotype, AG and GG genotypes had a significantly reduced risk of ESCC. |
| Pubmed ID | 23872665 |
| Year | 2013 |
| Title | A genetic polymorphism in lincRNA-uc003opf.1 is associated with susceptibility to esophageal squamous cell carcinoma in Chinese populations |