Welcom to using CHG!
Introduce
Hallmarks of cancer depict the logical framework for conceptualize the variety of neoplastic diseases, including Sustaining Proliferative Signaling, Evading Growth Suppressors, Resisting Cell Death, Enabling Replicative Immortality, Inducing Angiogenesis and Activating Invasion and Metastasis, Genome Instability and Mutation, Tumor-Promoting Inflammation, Reprogramming Energy Metabolism and Evading Immune Destruction. The comprehensive database constructed by hallmarks feature set including specific gene sets, DNA mutation and epigenetic information provided us a new view for analysis on diversity and development of cancers. To this end, we developed a specifically designed database Cancer Hallmark Genes (CHG).
Include
CHG database is focused on integrating and annotating Hallmark features’ potential roles in human cancer processes. According to the key words from 3 different professional experts to determine the Hallmark characteristics, based on the method of text mining from KEGG and other databases to determine the Hallmark related pathways, as well as the associated genes in 34 types of cancer. The current release of CHG Database was collected 2838 genes (in 55 pathways) related to hallmarks. To help to promote the analysis of carcinogenesis, we comprehensive collected the driven mutation, differentially expression methylation and CNV gene data from TCGA, and mapped them into hallmarks and corresponding statistical analysis results including the frequency of mutation (e.g. missense, deletion, insertion etc.), methylation and CNV (e.g. loss or gain) in each genes. We analyzed the relationship among ten hallmarks and clustered them into four classes: 1) Reprogramming Energy Metabolism (REM). 2) Activating Invasion and Metastasis (AIM), Evading Growth Suppressors (EGS), Enabling Replicative Immortality (ERI) and Sustaining Proliferative Signaling (SPS). 3) Genome Instability and Mutation (GIM). 4) Tumor-Promoting Inflammation (TPI), Evading Immune Destruction (EID), Resisting Cell Death (RCD) and Inducing Angiogenesis (IA).
Inquire
The database allows users to browse from two aspects, hallmark classification and tumor typing, and also provide users with a separate search interface to search for the genes of interest. For each gene in the database, we provide the following information: (1) Gene annotation information. These included mutation, methylation and copy number variation of Hallmark genes. (2) Network topology information. Structure the Hallmark genes interaction and regulatory network, and calculate the degree, clustering coefficient and betweenness centrality information of the gene in different hallmark networks. (3) The variation frequency information. Combined with the variation data in the TCGA, CHG calculated the frequency of gene of mutation, methylation and copy number variation in different cancer types, and graphical display respectively the proportion of different types of variation.
Browse Hallmarks
Select a hallmark
Show topological properties of all genes in this hallmark
Table of detail information of this gene
Graphs of variation types of this gene in BRCA
Browse cancers
Select a cancer type
Show frequency of variation types of all genes in this cancer