CellSNVReg is a cellular resolved resource that systematically characterizes SNV-induced regulatory perturbations across transcriptional, post-transcriptional, and proteomic levels. By integrating scRNA-seq, spatial transcriptomics, and scATAC-seq data from 56 tissue types comprising 4,602,505 cells and spatial spots, CellSNVReg identifies 248,695 perturbed SNVs across six regulatory dimensions: miRNA-target, TF-target, enhancer-target, RBP-target, protein-protein interactions, and neoantigen generation. The resource provides both qualitative and quantitative annotations, enabling the discovery of cell type-specific driver SNVs across diseases and elucidating their effects on cellular phenotypes and therapeutic strategies.
Explore the downstream effects of SNV perturbation through our comprehensive analytical tools
Explore distribution and statistics of SNV-mediated regulatory perturbations across cell types in each sample.
Analyze the differential expression of SNV perturbed target genes across different cell types to uncover cell type specific regulatory effects.
Assess the functional consequences of SNV perturbations through enrichment analysis and pathway annotation to elucidate their roles in cellular and molecular processes.
Analyze the impact of SNV perturbations on cell state and heterogeneity to reveal cell state reprogramming.
Evaluate stemness characteristics and related regulatory networks affected by SNVs in different cell populations.
Analyze SNV perturbed intercellular communication networks to reveal cell interaction patterns and ligand-receptor pairs.
Analyze SNV perturbed cellular metabolic characteristics and pathway activities to uncover cell metabolic reprogramming.
Analyze the impact of SNV perturbations on drug targets in disease contexts to inform novel therapeutic strategies.