Welcome to IEAtlas!

Identifying the entirety of Human leukocyte antigen (HLA) presented peptides are indispensable for the development of cancer immunotherapies, defined as the immunopeptidome. Epitopes derived from non-coding regions expand immunopeptidome in cancer. Here, we developed the IEAtlas database to provide an atlas of HLA-presented immunogenic epitopes derived from non-coding regions.

IEAtlas:

I)

re-analyzes public HLA immunopeptidome mass spectrometry data from 2,747 samples of 15 cancer types and 30 non-cancerous tissues

II)

constructs a theory library including 475,782 translated ncORFs from non-coding regions

III)

detects a total of 145,366 and 100,504 non-canonical epitopes binding by HLA I and II respectively

IV)

queries the predicted information of both presentation features and recognition features

V)

provides the clinical relevance of corresponding genes