Basic information of DCTN1 :
| Official Symbol of Gene | DCTN1 |
| Species | Homo sapiens |
| Entrez Gene ID | 1639 |
| Official Full Name | dynactin subunit 1 |
| Also known as | P135; DP-150; DAP-150 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000204843 MIM:601143; AllianceGenome:HGNC:2711 |
| Map Location | 2p13.1 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | both parents |
| Sample Size | 100 patients had a relapsing–remitting form of MS and 100 cases were primary progressive |
Literature information of multiple sclerosis :
| Pubmed ID | 17824900 |
| Year | 2007 |
| Title | The p150 subunit of dynactin (DCTN1) gene in multiple sclerosis |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | The results indicate that the DCTN1 gene is probably not influencing susceptibility to neurodegeneration in MS |
| Mechanism/Pathway | Mutations in the p150 subunit of the axonal transport protein dynactin (DCTN1) have been reported in patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) |
