Basic information of DROSHA :
| Official Symbol of Gene | DROSHA |
| Species | Homo sapiens |
| Entrez Gene ID | 29102 |
| Official Full Name | drosha ribonuclease III |
| Also known as | RN3; ETOHI2; RNASEN; RANSE3L; RNASE3L; HSA242976 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000113360 MIM:608828; AllianceGenome:HGNC:17904 |
| Map Location | 5p13.3 |
Sample information of multiple sclerosis:
| Detected Sample | Peritoneal macrophages |
| Sample Detail | N/A |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | Twenty-one RRMS patients/ 21 healthy age and sex-matched volunteers |
Literature information of multiple sclerosis :
| Pubmed ID | 25439752 |
| Year | 2014 |
| Title | Overexpression of microRNA biogenesis machinery: Drosha, DGCR8 and Dicer in multiple sclerosis patients |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | The expression levels of these components in relapsing remitting multiple sclerosis (RRMS) patients were significantly up-regulated in comparison to healthy controls. DGCR8 was up-regulated 4.9 times in RRMS patients versus healthy controls, and Drosha was up-regulated 3.58 times. Additionally, the expression level of Dicer was 2.11 times higher in RRMS patients than the healthy controls. In conclusion, our results suggest that overexpression of Drosha, Dicer and DGCR8 may contribute to the pathogenesis of MS. Further investigation may introduce microRNA biogenesis machinery as MS markers and therapeutic targets |
| Mechanism/Pathway | miRNA synthesis begins in the nucleus, where the primary miRNA transcript is transcribed by RNA polymerase II and subsequently is processed by a microprocessor complex to produce several precursor miRNA (pre-miRNA). RNA endonuclease III, Drosha inside the nucleus, and DiGeorge syndrome critical region gene 8 (DGCR8 or Pasha) construct the microprocessor complex |
