Basic information of DICER1 :

Official Symbol of Gene	DICER1
Species	Homo sapiens
Entrez Gene ID	23405
Official Full Name	dicer 1, ribonuclease III
Also known as	DCR1; GLOW; MNG1; aviD; Dicer; HERNA; RMSE2; Dicer1e; K12H4.8-LIKE
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000100697 MIM:606241; AllianceGenome:HGNC:17098
Map Location	14q32.13

Sample information of multiple sclerosis:

Detected Sample	Peritoneal macrophages
Sample Detail	N/A
Detected Method	RT-PCR
Disease	MS
Disease subtype	RRMS
Population	N/A
Sample Size	Twenty-one RRMS patients/ 21 healthy age and sex-matched volunteers

Literature information of multiple sclerosis :

Pubmed ID	25439752
Year	2014
Title	Overexpression of microRNA biogenesis machinery: Drosha, DGCR8 and Dicer in multiple sclerosis patients

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	The expression levels of these components in relapsing remitting multiple sclerosis (RRMS) patients were significantly up-regulated in comparison to healthy controls. DGCR8 was up-regulated 4.9 times in RRMS patients versus healthy controls, and Drosha was up-regulated 3.58 times. Additionally, the expression level of Dicer was 2.11 times higher in RRMS patients than the healthy controls. In conclusion, our results suggest that overexpression of Drosha, Dicer and DGCR8 may contribute to the pathogenesis of MS. Further investigation may introduce microRNA biogenesis machinery as MS markers and therapeutic targets
Mechanism/Pathway	miRNA synthesis begins in the nucleus, where the primary miRNA transcript is transcribed by RNA polymerase II and subsequently is processed by a microprocessor complex to produce several precursor miRNA (pre-miRNA). RNA endonuclease III, Drosha inside the nucleus, and DiGeorge syndrome critical region gene 8 (DGCR8 or Pasha) construct the microprocessor complex