Basic information of CD40LG :
| Official Symbol of Gene | CD40LG |
| Species | Homo sapiens |
| Entrez Gene ID | 959 |
| Official Full Name | CD40 ligand |
| Also known as | IGM; IMD3; TRAP; gp39; CD154; CD40L; HIGM1; T-BAM; TNFSF5; hCD40L |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000102245 MIM:300386; AllianceGenome:HGNC:11935 |
| Map Location | Xq26.3 |
Sample information of multiple sclerosis:
| Detected Sample | Peritoneal macrophages |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | MS (n = 26) /Healthy volunteers (n = 55) |
Literature information of multiple sclerosis :
| Pubmed ID | 27339331 |
| Year | 2016 |
| Title | T-cell activation and HLA-regulated response to smoking in the deep airways of patients with multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | our results confirm that smoking induces an increase of alveolar macrophages in BAL, and further defined a significant attenuation of this response in carriers of the HLA-DRB1*15 allele, in both MS patients and healthy controls. This first systematic investigation of the immune response in the lungs of smokers and non-smokers diagnosed with MS, thus suggests an MS-associated lung T-cell phenotype, involvement of a specific T-cell response to smoke, and a genetic regulation of the macrophage response |
| Mechanism/Pathway | In the BAL, non-smokers with MS showed an increased preformed CD40L expression in CD4 + T-cells while smokers displayed an increase in proliferating (Ki-67+) T-cells. |
