Basic information of CYP27B1 :
| Official Symbol of Gene | CYP27B1 |
| Species | Homo sapiens |
| Entrez Gene ID | 1594 |
| Official Full Name | cytochrome P450 family 27 subfamily B member 1 |
| Also known as | VDR; CP2B; CYP1; PDDR; VDD1; VDDR; VDDRI; CYP27B; P450c1; CYP1alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000111012 MIM:609506; AllianceGenome:HGNC:2606 |
| Map Location | 12q14.1 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | Quantitative real time-PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iran |
| Sample Size | RRMS patients and 50 normal controls |
Literature information of multiple sclerosis :
| Pubmed ID | 27792005 |
| Year | 2016 |
| Title | Down-regulation of CYP27B1 gene expression in Iranian patients with relapsing-remitting multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | A significant decrease in the expression level of CYP27A1 in female patients could indicate their greater vulnerability to MS than the male patients |
| Mechanism/Pathway | Multiple sclerosis (MS) as a complex neurological disease can be due to vitamin D deficiency. CYP27B1 is referred to as a vitamin D metabolizing enzyme. |
