Basic information of TBX21 :

Official Symbol of Gene	TBX21
Species	Homo sapiens
Entrez Gene ID	30009
Official Full Name	T-box transcription factor 21
Also known as	TBET; IMD88; T-PET; T-bet; TBLYM
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000073861 MIM:604895; AllianceGenome:HGNC:11599
Map Location	17q21.32

Sample information of multiple sclerosis:

Detected Sample	peripheral blood
Sample Detail	N/A
Detected Method	Real-Time PCR
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	eight newly diagnosed (one man and seven women) and eight (two men and six women) IFN-1b-treated patients injection and the mean age of the patients was 33.91 + 8.4. Blood collection from IFN-1b-treated patients was performed 24–48 h after IFN1b injection

Literature information of multiple sclerosis :

Pubmed ID	30178232
Year	2018
Title	Immunoregulatory Effects of Silymarin on Proliferation and Activation of Th1 Cells Isolated from Newly Diagnosed and IFN-1b-Treated MS Patients

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	IFN-γ level at a concentration of 100 μM in comparison with DMSO. Our findings here clearly show that silymarin is an effective regulator for Th1 response in vitro condition. It not only suppresses Th1 proliferating activity but also inhibits T-bet gene expression and IFN-γ production by these cells
Mechanism/Pathway	T-bet gene expression was significantly decreased in Th1 cells isolated from newly diagnosed and IFN-β-treated RRMS patients after treatment with silymarin compared to DMSO control.