Basic information of MBP :

Official Symbol of Gene	MBP
Species	Homo sapiens
Entrez Gene ID	4155
Official Full Name	myelin basic protein
Also known as	N/A
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000197971 MIM:159430; AllianceGenome:HGNC:6925
Map Location	18q23

Sample information of multiple sclerosis:

Detected Sample	peripheral blood
Sample Detail	N/A
Detected Method	PCR
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	N/A

Literature information of multiple sclerosis :

Pubmed ID	10203578
Year	1999
Title	Expression of Green Fluorescent Protein in Oligodendrocytes in a Time- and LevelControllable Fashion with a TetracyclineRegulated System

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	Our data indicate that this inducible gene expression system is useful for the study of gene function in vivo and for the development of transgenic animal models relevant to human diseases such as multiple sclerosis
Mechanism/Pathway	Upon the addition of doxycycline (DOX, a tetracycline derivative), tet transactivators became activated and bound to one or more TRE, leading to the activation of the CMV promoter and the expression of GFP in oligodendrocytes. We have successfully expressed GFP and luciferase at high levels in oligodendrocytes in a timeand dose-dependent fashion. In the absence of DOX, there was almost no GFP expression in oligodendroglial cultures. Graded levels of GFP expression were observed after induction with DOX (0.5 to 12.5 jig/ml).