Basic information of CCR2 :
| Official Symbol of Gene | CCR2 |
| Species | Homo sapiens |
| Entrez Gene ID | 729230 |
| Official Full Name | C-C motif chemokine receptor 2 |
| Also known as | CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000121807 MIM:601267; AllianceGenome:HGNC:1603 |
| Map Location | 3p21.31 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | pre-B cell |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 12554737 |
| Year | 2003 |
| Title | A Highly Selective CCR2 Chemokine Agonist Encoded by Human Herpesvirus 6 |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | It is suggested that vCCL4 during reactivation of the virus in for example monocyte-derived microglia could perhaps be involved in the pathogenesis of the CCR2-dependent disease, multiple sclerosis |
| Mechanism/Pathway | vCCL4 was found to cause calcium mobilization as efficiently as the endogenous chemokine ligand CCL2 through the CCR2 receptor, whereas the virally encoded chemokine did not affect any of the other 17 human chemokine receptors tested. Mutual cross-desensitization between CCL2 and vCCL4 was demonstrated in the CCR2-transfected cells |
