Basic information of FGF2 :

Official Symbol of Gene	FGF2
Species	Homo sapiens
Entrez Gene ID	2247
Official Full Name	fibroblast growth factor 2
Also known as	BFGF; FGFB; FGF-2; HBGF-2
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000138685 MIM:134920; AllianceGenome:HGNC:3676
Map Location	4q28.1

Sample information of multiple sclerosis:

Detected Sample	Brain
Sample Detail	oligodendrocyte precursor cell
Detected Method	PCR
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	N/A

Literature information of multiple sclerosis :

Pubmed ID	14769383
Year	2003
Title	Inducible expression of FGF2 by a rat oligodendrocyte precursor cell line promotes CNS myelination in vitro

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	The data presented here demonstrate that upon induction with Dox, CG4-FGF2 cells retain their capacity to differentiate in vitro. Additionally, we provide evidence that FGF2 release by engineered cells enhance proliferation and migration of cells of the oligodendrocyte lineage without preventing them to differentiate and myelinate axons in vitro
Mechanism/Pathway	we have developed a genetically modified CG4 cell line (CG4-FGF2), which are able to release significant amounts of fibroblast growth factor 2 (FGF2) in a controlable fashion in vitro.