Basic information of RGCC :

Official Symbol of Gene	RGCC
Species	Homo sapiens
Entrez Gene ID	28984
Official Full Name	regulator of cell cycle
Also known as	RGC32; RGC-32; C13orf15; bA157L14.2
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000102760 MIM:610077; AllianceGenome:HGNC:20369
Map Location	13q14.11

Sample information of multiple sclerosis:

Detected Sample	Brain
Sample Detail	T cells and macrophages
Detected Method	Real-time PCR
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	Brain tissue Frozen brain tissue specimens acquired at autopsy from eight patients with a definite diagnosis of MS

Literature information of multiple sclerosis :

Pubmed ID	23000427
Year	2012
Title	Dual role of Response gene to complement-32 in multiple sclerosis

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	Our data suggest that RGC-32 plays a dual role in MS, both as a regulator of T-cells mediated apoptosis and as a promoter of TGF-β-mediated profibrotic effects in astrocytes
Mechanism/Pathway	FasL mRNA expression was significantly reduced after RGC-32 silencing, indicating a role for RGC-32 in the regulation of FasL expression. In addition, the expression of Akt1, cyclin D1, and IL-21 mRNA was significantly increased during MS relapses when compared to levels in healthy controls. Furthermore, we investigated the role of RGC-32 in TGF-β-induced extracellular matrix expression in astrocytes. Blockage of RGC-32 using small interfering RNA significantly inhibits TGF-β induction of procollagen I, fibronectin and of the reactive astrocyte marker α-smooth muscle actin (α-SMA).