Basic information of APOD :
| Official Symbol of Gene | APOD |
| Species | Homo sapiens |
| Entrez Gene ID | 347 |
| Official Full Name | apolipoprotein D |
| Also known as | N/A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000189058 MIM:107740; AllianceGenome:HGNC:612 |
| Map Location | 3q29 |
Sample information of multiple sclerosis:
| Detected Sample | Brain |
| Sample Detail | Reagents Human glioblastoma cells |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 23715769 |
| Year | 2013 |
| Title | Binding and Repressive Activities of Apolipoprotein E3 and E4 Isoforms on the Human ApoD Promoter |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | we observed an inverse correlation between ApoD and ApoE mRNA expression during development and in several regions of the mouse brain, notably in the cortex, hippocampus, plexus choroid, and cerebellum. This negative correlation was also observed for cortex layers IV–VI based on a new Transcriptomic Atlas of the Mouse Neocortical Layers. These findings reveal a new function for ApoE by regulating ApoD gene expression |
| Mechanism/Pathway | overexpression of ApoE3 and ApoE4 isoforms but not ApoE2 significantly inhibited the ApoD promoter activity in U87 cells (E3/E3 genotype) cultured under normal or different stress conditions while ApoE knock-down by siRNA had a converse effect |
