Basic information of PTPRC :
| Official Symbol of Gene | PTPRC |
| Species | Homo sapiens |
| Entrez Gene ID | 5788 |
| Official Full Name | protein tyrosine phosphatase receptor type C |
| Also known as | LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; IMD105 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000081237 MIM:151460; AllianceGenome:HGNC:9666 |
| Map Location | 1q31.3-q32.1 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | German |
| Sample Size | 347 controls /454 MS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 12028593 |
| Year | 2002 |
| Title | PTPRC (CD45) is not associated with multiple sclerosis in a large cohort of German patients |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | The 77C→G transition in exon 4 of the PTPRC gene may contribute to MS susceptibility only in very few families, if at all, but it is not relevant for the majority of MS cases, including virtually all German patients |
| Mechanism/Pathway | alternative splicing of exons 4 (CD45RA), 5 (CD45RB) and 6 (CD45RC) (CD45RO, exons 4–6 spliced out). The 77C→G transition does not change the amino acid sequence, but it is probably part of a motif necessary for splicing leading to the isoform CD45RA |
