Basic information of CDR3 :
| Official Symbol of Gene | CDR3 |
| Species | Homo sapiens |
| Entrez Gene ID | 8163 |
| Official Full Name | Cerebellar degeneration-related autoantigen-3 |
| Also known as | N/A |
| Gene Type | other |
| dbXrefs | MIM:602197 |
| Map Location | 17q25 |
Sample information of multiple sclerosis:
| Detected Sample | Frozen spinal cord tissues |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MSã€EAE |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 8064235 |
| Year | 1994 |
| Title | Detection of Human T Lymphotrophic Virus Type I (HTLV-I) Proviral DNA and Analysis of T Cell Receptor VB CDR3 Sequences in Spinal Cord Lesions of HTLV-I-associated Myelopathy/Tropical Spastic Paraparesis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | The present results suggest that T cells containing restricted V3 CDK3 motifs, which are also found in MS and EAE, become activated upon HTLV-I infection and infiltrate into the spinal cord lesions of HAM/TSP patients. |
| Mechanism/Pathway | This indicates that the demyelination of the spinal cord by HTLV-I as a result of viral infection of oligodendrocytes or neuronal cells is unlikely. The T cell receptor V/3 gene sequence from lymphocytes in the spinal cord lesions taken from the same HAM/TSP autopsy cases revealed unique and restricted CDR3 motifs, CASSLXG(G) (one-letter amino acid. X is any amino acid), CASSPT(G), and CASSGRL which are similar to those described in T cells from brain lesions of multiple sclerosis (MS) and in a rat T cell clone derived from experimental allergic encephalomyelitis (EAE) lesions |
