Basic information of RORC :
| Official Symbol of Gene | RORC |
| Species | Homo sapiens |
| Entrez Gene ID | 6097 |
| Official Full Name | RAR related orphan receptor C |
| Also known as | TOR; RORG; RZRG; IMD42; NR1F3; RZR-GAMMA |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000143365 MIM:602943; AllianceGenome:HGNC:10260 |
| Map Location | 1q21.3 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 23 patients with relapsing-remitting MS (RRMS) |
Literature information of multiple sclerosis :
| Pubmed ID | 26601116 |
| Year | 2015 |
| Title | Immunologic and MRI markers of the therapeutic effect of IFN-b-1a in relapsing-remitting MS |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Findings indicate that IFN-b-1a suppresses Th22 and Th17 cell responses, which were associated with decreased MRI-detectable demyelination |
| Mechanism/Pathway | IFN-b-1a induced reductions in transcription factor AHR, T-bet, and retinoic acid–related orphan nuclear hormone receptor C (RORc) gene expression, while it increased GATA3’s expression in CD41 cells |
