Basic information of IFNAR2 :

Official Symbol of Gene	IFNAR2
Species	Homo sapiens
Entrez Gene ID	3455
Official Full Name	interferon alpha and beta receptor subunit 2
Also known as	IFN-R; IMD45; IFNABR; IFNARB; IFN-R-2; IFN-alpha-REC
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000159110 MIM:602376; AllianceGenome:HGNC:5433
Map Location	21q22.11

Sample information of multiple sclerosis:

Detected Sample	Peripheral blood
Sample Detail	N/A
Detected Method	PCR
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	30 healthy women 18 to 70 years old

Literature information of multiple sclerosis :

Pubmed ID	27095999
Year	2015
Title	Inhibition of G-Protein βγ Signaling Decreases Levels of Messenger RNAs Encoding Proinflammatory Cytokines in T Cell Receptor-Stimulated CD4+ T Helper Cells

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	Inhibiting Gβγ to produce these shifts in cytokine mRNA production might be beneficial for patients with autoimmune diseases such as rheumatoid arthritis (RA), Crohn’s disease (CD), psoriasis, multiple sclerosis (MS), and Hashimoto’s thyroiditis (HT), in which both IFN-γ and IL-17A are elevated.
Mechanism/Pathway	Gallein and Gβ1 siRNA decreased interferon-γ (IFN-γ) and IL-17A mRNA levels in TCR-stimulated CD4+ T cells grown under TH1-promoting conditions. Inhibiting Gβγ also decreased mRNA levels of STAT4, which plays a positive role in TH1 differentiation and IL-17A production. Moreover, mRNA levels of the STAT4-regulated TH1-associated proteins, IL-18 receptor β chain (IL-18Rβ), mitogen-activated protein kinase kinase kinase 8 (MAP3K8), lymphocyte activation gene 3 (LAG-3), natural killer cell group 7 sequence (NKG7), and oncostatin M (OSM) were also decreased upon Gβγ inhibition. Gallein also increased IL-4, IL-5, IL-9, and IL-13 mRNA levels in TCR-stimulated memory CD4+ T cells grown in TH2-promoting conditions