Basic information of IL-10 :
| Official Symbol of Gene | IL-10 |
| Species | Homo sapiens |
| Entrez Gene ID | 3586 |
| Official Full Name | interleukin 10 |
| Also known as | CSIF; TGIF; GVHDS; IL-10; IL10A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000136634 MIM:124092; AllianceGenome:HGNC:5962 |
| Map Location | 1q32.1 |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | astrocytoma cell |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | A172 and 1321N1 |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 25689952 |
| Year | 2015 |
| Title | Direct immunomodulatory influence of IFN-b on human astrocytoma cells |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | We found a significant dose-dependent increase in IL-10 gene expression in A172 and 1321N1 cells treated with IFN-b or LPS/IFN-g/IFN-b. Moreover, a significant decrease was observed in iNOS expression suggesting a similar mechanism of action for both cells. Eventually there were no significant changes concerning the modulation of the MMP-9 and TIMP-1 in response to IFN-b treatment. In part, the immunomodulatory effect of IFN-b may be due to increase of IL-10 and suppression of iNOS expression in astrocytes of brain tissue. |
| Mechanism/Pathway | IFN-b could significantly promote IL-10 expression in astrocytoma cell lines stimulated with LPS and IFN-g in a dose-dependent manner and had potential effect on increasing IL-10 expression alone or with LPS/IFN-g. |
