Basic information of ERVW-1 :
| Official Symbol of Gene | ERVW-1 |
| Species | Homo sapiens |
| Entrez Gene ID | 30816 |
| Official Full Name | endogenous retrovirus group W member 1, envelope |
| Also known as | ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000242950 MIM:604659; AllianceGenome:HGNC:13525 |
| Map Location | 7q21.2 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | human T-lymphplastic leukaemia (MOLT-4) cell |
| Detected Method | PCR |
| Disease | neurodegenerative disease |
| Disease subtype | leukaemia and multiple sclerosis |
| Population | ATCC CRL1582; Manassas, VA, USA) and the Fanconi anaemia (FA) acute myeloid leukaemia (FA-AML1) cell |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 27576335 |
| Year | 2016 |
| Title | Silver nanoparticles exhibit size-dependent differential toxicity and induce expression of syncytin-1 in FA-AML1 and MOLT-4 leukaemia cell lines |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | AgNPs induce syncytin-1 expression in leukaemic cell lines |
| Mechanism/Pathway | FA-AML1 cells were more sensitive overall than MOLT-4 to treatment with the smaller 7nm sized AgNp’s being the most toxic in these cells |
