Basic information of IL17A :
| Official Symbol of Gene | IL17A |
| Species | Homo sapiens |
| Entrez Gene ID | 3605 |
| Official Full Name | interleukin 17A |
| Also known as | IL17; CTLA8; IL-17; ILA17; CTLA-8; IL-17A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000112115 MIM:603149; AllianceGenome:HGNC:5981 |
| Map Location | 6p12.2 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | optic neuritis (ON) |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 40patients with ON/164 control |
Literature information of multiple sclerosis :
| Pubmed ID | 29736281 |
| Year | 2018 |
| Title | Association of Optic Neuritis with CYP4F2 Gene Single Nucleotide Polymorphism and IL-17A Concentration |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | The higher IL-17A levels were found to be associated with ON, while allele A at rs1558139 was associated only with ON with MS in male patients |
| Mechanism/Pathway | In the central nervous system, IL-17A is associated with a wide range of neuropathological disorders (MS, epilepsy episodes of ischemic brain disorders). IL-17A, acting on spinal nerve roots and the spinal cord, contributes to neuropathic and inflammatory pain promotion through pain receptors.Also, IL-17A is very important to damaged sympathetic axons which innervate the cornea regeneration and growth. |
