Basic information of TNFSF13B :
| Official Symbol of Gene | TNFSF13B |
| Species | Homo sapiens |
| Entrez Gene ID | 10673 |
| Official Full Name | TNF superfamily member 13b |
| Also known as | DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNLG7A; TNFSF20 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000102524 MIM:603969; AllianceGenome:HGNC:11929 |
| Map Location | 13q33.3 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | white blood cells |
| Detected Method | TaqMan assay |
| Disease | giant cell arteritis (GCA) and systemic sclerosis (SSc) |
| Disease subtype | N/A |
| Population | European |
| Sample Size | 1,728 biopsy-proven GCA patients from 4 European cohorts, 4,584 SSc patients from 3 European cohorts and 5,160 ethnically-matched healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 30586461 |
| Year | 2018 |
| Title | A TNFSF13B functional variant is not involved in systemic sclerosis and giant cell arteritis susceptibility |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Our data suggest that the TNFSF13B functional variant does not contribute to the genetic network underlying GCA and SSc |
| Mechanism/Pathway | The TNFSF13B (TNF superfamily member 13b) gene encodes BAFF, a cytokine with a crucial role in the differentiation and activation of B cells |
